Free gene check
Check MTHFR from raw DNA
MTHFR C677T is read from rs1801133: GG is the typical form, AG one copy, AA two. This page reads it, and A1298C (rs1801131) if your file has it, and shows the row of our MTHFR guide your letters fall in.
It runs in your browser. Your file is never uploaded, there is no account, and it is free. We count that a check ran and whether the positions were in your file, never your result.
Choose or drop your raw DNA file
.txt · .csv · .zip · .vcf · .vcf.gz
Run the full analysis on this file
The free DNA report reads the same file for ancestry across 15 world regions, traits, medication genes and both family lines. Your DNA story opens straight away with no account; the full report opens after a code sent to your email.
Questions
How do I read MTHFR from my AncestryDNA or 23andMe raw data?
Drop the raw file on healthosx.com/dna/genes/mthfr. It reads rs1801133 (C677T; on the plus strand GG is typical, AG one copy, AA two) and rs1801131 (A1298C) in your browser, with what our MTHFR guide says about your letters. Free, no account, never uploaded.
Does one copy of MTHFR C677T matter?
Rarely. Roughly 40% of people of European ancestry carry one copy, with about 65% of typical enzyme activity, and it has little practical effect.
Is a blood test more useful than the gene?
Yes. A blood homocysteine test tells you whether anything is actually happening, which the genotype only hints at.