What is a normal albumin/globulin ratio?

About 1.0 to 2.5 in most labs, often printed as 1.1–2.5 or 1.2–2.2. Below 1.0 is called low or "reversed".

How do you calculate the A/G ratio?

Globulin = total protein − albumin, then divide albumin by globulin. Albumin 4.4 g/dL with total protein 7.2 g/dL gives globulin 2.8 and an A/G ratio of 1.57.

What does a low A/G ratio mean?

Either albumin is low (liver disease, kidney loss, poor nutrition, inflammation) or globulin is high (long-running infection or inflammation, autoimmune disease, or a blood condition such as myeloma). A doctor reads it with your other results and may order a serum protein electrophoresis.

Albumin/globulin (A/G) ratio calculator and normal range

Short answer: The A/G ratio is albumin divided by globulin; globulin is total protein minus albumin. It is usually about 1.0 to 2.5. A low ratio means more globulin than albumin, which can come with inflammation, liver or kidney disease and some blood conditions; on its own it is a reason to look further, not a diagnosis.

Free calculator

Albumin/globulin (A/G) ratio calculator

A/G ratio = albumin ÷ globulin; globulin = total protein − albumin

Source: Busher JT. Serum albumin and globulin. In: Walker HK, Hall WD, Hurst JW, eds. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworths; 1990. Chapter 101.

Unit

Your report prints

Albumin

g/dL

Total protein

g/dL

From the same blood test

Your result

Enter the numbers from your lab report to see your result.

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A pointer, not a diagnosis. Talk to a doctor about your result, and sooner if you feel unwell.

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How to read the result

Low (below 1.0)< 1More globulin than albumin. It can come with a long-running inflammation or infection, liver disease, protein lost through the kidneys or, less often, a blood condition that makes too much of one antibody (such as myeloma). Talk to a doctor, who may ask for a protein electrophoresis test.
Typical (1.0 to 2.4)1 – 2.5In the usual range.
High (2.5 or above)≥ 2.5Less globulin than usual. It is often harmless, but it can come with a low antibody level. If you get a lot of infections, mention it to a doctor.

Your lab’s range

Labs print an A/G ratio range of about 1.0–2.5, often 1.1–2.5 or 1.2–2.2. The markers behind it have their own ranges: albumin about 3.5–5.0 g/dL (35–50 g/L) and total protein about 6.0–8.3 g/dL (60–83 g/L). Your lab’s range comes first.

How it is worked out

A/G ratio = albumin ÷ globulin; globulin = total protein − albumin

Source

Busher JT. Serum albumin and globulin. In: Walker HK, Hall WD, Hurst JW, eds. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworths; 1990. Chapter 101.

The markers it uses

Albumin Globulin Total Globulin

Questions

What is a normal albumin/globulin ratio?: About 1.0 to 2.5 in most labs, often printed as 1.1–2.5 or 1.2–2.2. Below 1.0 is called low or "reversed".
How do you calculate the A/G ratio?: Globulin = total protein − albumin, then divide albumin by globulin. Albumin 4.4 g/dL with total protein 7.2 g/dL gives globulin 2.8 and an A/G ratio of 1.57.
What does a low A/G ratio mean?: Either albumin is low (liver disease, kidney loss, poor nutrition, inflammation) or globulin is high (long-running infection or inflammation, autoimmune disease, or a blood condition such as myeloma). A doctor reads it with your other results and may order a serum protein electrophoresis.

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A pointer, not a diagnosis. Talk to a doctor about your result, and sooner if you feel unwell. Reference ranges are general-population guidance compiled from common clinical laboratories, not a diagnosis. Lab-to-lab ranges differ. Always read your results with your doctor.